FIELD: chemistry.
SUBSTANCE: invention relates to synthesis of chemical substances and specifically to production of coordination compounds of metals with derivatives of 1,3-thiazoles, which can be used as therapeutic agents, including anticancer drugs. Method involves preparation of a solution containing a two-component water-ethanol solvent with a volume ratio of components in it of 1:1, a proligand and an equimolar amount of sodium hydroxide. Further, electrolysis of the obtained solution is carried out with zinc electrodes at direct current with electric current density of 5 mA/cm2 and subsequent separation of the precipitate by filtration under vacuum. Proligand used is (N-phenyl-2-imino)-4-oxo-thiazolidin-5-yl acetic acid. Weight ratio of water : ethanol : sodium hydroxide : (N-phenyl-2-imino)-4-oxo-thiazolidin-5-yl acetic acid is equal to 53.20:42.00:0.65:4.15.
EFFECT: obtaining a coordination compound of zinc with a residue of (N-phenyl-2-imino)-4-oxo-thiazolidin-5-yl acetic acid, having high penetrating power.
1 cl, 4 dwg, 3 tbl, 1 ex
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