METHOD OF PRODUCING PURE PREPARATIONS OF FLAVONOIDS FROM COMPRESSION ASPEN WOOD Russian patent published in 2025 - IPC B01D11/02 B01D15/40 A61K31/05 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to methods for extracting flavonoids. Method of producing pure preparations of flavonoids from compression wood includes preparation of raw material, extraction of extractive substances with subsequent production of individual components, wherein the raw material used is compression wood of European aspen Populus tremula, which is dried, crushed to particle size of not more than 1 mm and then dried in a vacuum drying cabinet at temperature of 40 °C. Obtained dry sawdust is then extracted in a Soxhlet apparatus in two steps: hexane and acetone for 10 hours each. Further, the acetone extract is evaporated on a rotary evaporator to a minimum volume, a five-fold excess of deionised water is added to obtain a suspension and lyophilized. Extraction of pure preparations of flavonoids is carried out by supercritical fluid chromatography with separation on modified silica gel sorbents containing ethylpyridine or diol graft groups to obtain preparations of flavonoids with purity of at least 80%.

EFFECT: disclosed method of producing pure preparations of flavonoids from compression wood provides high output of pure preparations of flavonoids.

1 cl, 4 dwg, 2 tbl, 1 ex