AZO DERIVATIVES OF 5-AMINOSALICYLIC ACID, CAPABLE OF INHIBITING FORMATION OF END PRODUCTS OF GLYCATION Russian patent published in 2025 - IPC C07D491/56 C07D213/16 A61K31/436 A61K31/44 A61P3/10 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel azo compounds based on 5-aminosalicylic acid of general formula (I), having high antiglycating activity (ability to block formation of end products of glycation).

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where R¹ = CH₃, H and other pharmaceutically acceptable cations such as Na, K, and R² = R³ = H, or R² and R³ together form a substitute of type CR⁵R⁶, where R⁵ = H, CH₃ and R⁶ = H, CH₃ and other linear alkyl substitutes, such as C₂H₅, n-C₃H₇, n-C₇H₁₅, n-C₈H₁₇; R⁴ = Et₃NH, H and other pharmaceutically acceptable cations of organic and inorganic nature, such as K, NH₄.

EFFECT: novel compounds are obtained, which are effective inhibitors of formation of end products of glycation and can be widely used in medicine in the treatment of complications of diabetes mellitus, atherosclerosis, rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, cataracts, diseases associated with aging.

2 cl, 4 dwg, 4 tbl, 18 ex