BIS[1,2,4]TRIAZOLO[4,3-b:3',4'-f][1,2,4,5]TETRAZINES WITH ANTI-GLYCATING, ANTI-GLYCOXIDATION AND ANTIPLATELET ACTIVITY Russian patent published in 2021 - IPC A61K31/4196 C07D249/16 

Abstract RU 2755897 C1

FIELD: medicine.

SUBSTANCE: invention relates to derivatives of a new heterocyclic system: 1,8-diarylbis[1,2,4]triazolo[4,3-b:3',4'-f][1,2,4,5]tetrazines of the general formula IIa-c, which have anti-glycating, anti-glycoxidation and antiplatelet activities.

EFFECT: provided is ability to block the formation of glycation end products and pathological consequences of this process.

1 cl, 4 tbl, 7 ex

Similar patents RU2755897C1

Title Year Author Number
3-GUANIDINOAZOLO[1,2,4,5]TETRAZINES HAVING ANTIGLYCATING ACTIVITY AND A PROCESS FOR THEIR PREPARATION 2017
  • Ishmetova Rashida Irshotovna
  • Ignatenko Nina Konstantinovna
  • Rusinov Gennadij Leonidovich
  • Charushin Valerij Nikolaevich
  • Spasov Aleksandr Alekseevich
  • Petrov Vladimir Ivanovich
  • Sysoeva Valentina Andreevna
RU2668971C1
SODIUM SALT OF DIETHYL ETHER OF 4-OXO-1,4-DIHYDROPYRAZOLO[5,1-C]-1,2,4-TRIAZINE-3,8-DICARBOXYLIC ACID MONOHYDRATE 2015
RU2612300C1
2-(5-NITRONYLFURAN-2-YL)-5-METHYL-6-NITRO-1,2,4-TRIAZOLO[1,5-A]PYRIMIDIN-7(4N)-ONE AND SALTS THEREOF 2018
  • Chupakhin Oleg Nikolaevich
  • Charushin Valerij Nikolaevich
  • Rusinov Vladimir Leonidovich
  • Savateev Konstantin Valerevich
  • Ulomskij Evgenij Nartsissovich
  • Fedotov Viktor Vladimirovich
  • Petrov Vladimir Ivanovich
  • Spasov Aleksandr Alekseevich
  • Babkova Valentina Andreevna
  • Babkov Denis Aleksandrovich
RU2716715C2
USE OF HETEROCYCLIC HYDRAZONES AS AGENTS HAVING ANTIGLYCATING ACTIVITY 2016
  • Klimochkin Yurij Nikolaevich
  • Belenkaya Raisa Semenovna
  • Leonova Marina Valentinovna
  • Spasov Aleksandr Alekseevich
  • Petrov Vladimir Ivanovich
  • Vasilev Pavel Mikhajlovich
  • Kuznetsova Valentina Andreevna
  • Kovaleva Anastasiya Igorevna
RU2658819C2
PHARMACEUTICAL COMPOSITION OF ANTIGLYCATING ACTIVITY IN SOLID DOSAGE FORM IN FORM OF CAPSULES AND METHOD FOR PREPARATION THEREOF 2019
  • Kosolapov Vadim Anatolevich
  • Kotovskaya Svetlana Konstantinovna
  • Petrov Vladimir Ivanovich
  • Rusinov Vladimir Leonidovich
  • Sapozhnikova Irina Mikhajlovna
  • Smirnova Lyudmila Andreevna
  • Spasov Aleksandr Alekseevich
  • Stepanova Eleonora Fedorovna
  • Shevchenko Aleksandr Mikhajlovich
RU2738804C1
ANTI-TUBERCULOSIS AGENTS BEING 3,7-DISUBSTITUTED [1,2,4]TRIAZOLO[1,5-b][1,2,4,5]TETRAZINES 2022
  • Charushin Valerii Nikolaevich
  • Ishmetova Rashida Irshotovna
  • Ignatenko Nina Konstantinovna
  • Korotina Anna Vladimirovna
  • Beliaev Danila Vladimirovich
  • Vakhrusheva Diana Vladimirovna
  • Tolshchina Svetlana Gennadevna
  • Eremeeva Natalia Ivanovna
  • Krasnoborova Svetlana Iurevna
  • Rusinov Gennadii Leonidovich
RU2802300C1
SODIUM SALT OF 3-NITRO-4-OXO-1,4-DIHYDROPYRAZOLO[5,1-c]-1,2,4-TRIAZINE-8-CARBOXYLIC ACID, DIHYDRATE 2016
  • Rusinov Vladimir Leonidovich
  • Chupakhin Oleg Nikolaevich
  • Charushin Valerij Nikolaevich
  • Sapozhnikova Irina Mikhajlovna
  • Bliznik Anastasiya Mikhajlovna
  • Spasov Aleksandr Alekseevich
  • Petrov Vladimir Ivanovich
  • Kuznetsova Valentina Andreevna
  • Kovaleva Anastasiya Igorevna
  • Vasilev Pavel Mikhajlovich
  • Vorfolomeeva Viktoriya Viktorovna
RU2641107C1
APPLICATION OF SULFASALAZINE AS AN INHIBITOR OF THE FORMATION GLYCATION END PRODUCTS 2017
  • Shtyrlin Yurij Grigorevich
  • Spasov Aleksandr Alekseevich
  • Balakin Konstantin Valerevich
  • Kuznetsova Valentina Andreevna
  • Petrov Vladimir Ivanovich
  • Strelnik Aleksej Dmitrievich
RU2680844C1
INHIBITORS OF FORMATION OF GLYCATION END PRODUCTS BASED ON AZO-DERIVATIVE PHENYLSULPHONIC ACIDS 2016
  • Spasov Aleksandr Alekseevich
  • Shtyrlin Yurij Grigorevich
  • Balakin Konstantin Valerevich
  • Kuznetsova Valentina Andreevna
  • Petrov Vladimir Ivanovich
  • Strelnik Aleksej Dmitrievich
RU2634594C1
APPLICATION OF NITRO-DERIVATIVE PHENOL-SULPHONIC ACIDS AS INHIBITORS OF FINAL GLYCATION PRODUCTS FORMATION 2016
  • Spasov Aleksandr Alekseevich
  • Shtyrlin Yurij Grigorevich
  • Balakin Konstantin Valerevich
  • Ziganshin Ajrat Usmanovich
  • Kuznetsova Valentina Andreevna
  • Petrov Vladimir Ivanovich
  • Strelnik Aleksej Dmitrievich
RU2628605C1

RU 2 755 897 C1

Authors

Charushin Valerij Nikolaevich

Korotina Anna Vladimirovna

Tolshchina Svetlana Gennadevna

Rusinov Gennadij Leonidovich

Litvinov Roman Aleksandrovich

Babkova Valentina Andreevna

Sirotenko Viktor Sergeevich

Babkov Denis Aleksandrovich

Spasov Aleksandr Alekseevich

Dates

2021-09-22Published

2020-12-18Filed