FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing crystalline form III of a compound of formula (VII-1), having characteristic peaks observed at the following values of the lattice constant (d) 8.32, 6.10, 5.98, 5.51, 5.16, 5.07, 4.85, 4.70, 4.61, 4.35, 4.20, 4.06, 4.00, 3.95, 3.77, 3.73, 3.65, 3.42, 3.39, 3.36, 3.26, 3.23, 3.13, 3.09, 2.99, 2.81 and 2.52 Å on X-ray powder diffraction diagram. Method is carried out by alternately adding a crude compound of formula (VII-1-CR) and ice-cooled phosphate buffer to obtain a solution having pH of 4 to 5.5, concentration after desalination with a synthetic adsorbent. Bringing solution temperature to 20–25 °C, then crystalline form III is inoculated, isopropanol is added and mixed.
EFFECT: obtaining stable crystalline form III of the compound of formula (VII-1).
2 cl, 4 dwg, 12 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CRYSTALLINE FORMS OF DIAZABICLOCTANE DERIVATIVE AND A METHOD OF THEIR PRODUCTION | 2014 |
|
RU2801220C2 |
| CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF | 2014 |
|
RU2695219C2 |
| CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF | 2023 |
|
RU2840014C2 |
| METHOD OF PRODUCING A DIAZABICYCLOOCTANE DERIVATIVE AND INTERMEDIATE THEREOF | 2014 |
|
RU2719480C2 |
| NOVEL BETA-LACTAMASE INHIBITOR AND METHOD FOR PRODUCTION THEREOF | 2013 |
|
RU2693898C2 |
| NEW β-LACTAMASE INHIBITOR AND A METHOD OF ITS PRODUCTION | 2019 |
|
RU2800050C2 |
| OPTICALLY ACTIVE DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2591701C2 |
| BETA-LACTAMASE INHIBITORS | 2009 |
|
RU2445314C9 |
| (2S,5R)-5-[(BENZYLOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE | 2012 |
|
RU2610091C2 |
| METHOD OF PRODUCING HETEROCYCLIC COMPOUNDS, INCLUDING TRANS-7-OXO-6-(SULPHOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE AND ITS SALT | 2012 |
|
RU2769076C2 |
