LATANOPROST-BASED LIQUID MEDICAMENT AND METHOD FOR PREPARING SAME Russian patent published in 2025 - IPC A61K31/216 A61K9/08 A61K47/34 A61P27/02 A61P27/06 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to a method for preparing a latanoprost-based drug in a liquid form, characterized by the fact that the following initial components are used for preparation, mg in one ml: latanoprost 0.02-0.1; macrogol glyceryl ricinoleate – 0.2-0.6; polydronium chloride 0.01-0.05; phosphate-buffered saline (in terms of dry substance) 0.01-25; water – balance, wherein method includes preparing an aqueous solution of phosphate-buffered saline, a mixture of latanoprost with glyceryl ricinoleate and an aqueous solution of polydronium chloride, then a buffer solution is added to the mixture of latanoprost and macrogol glyceryl ricinoleate in parts, stirring with the introduction of each part until a homogeneous state, followed by adding an aqueous solution of polydronium chloride to the resulting mixture and stirring, and also relates to a latanoprost-based drug in liquid form.

EFFECT: group of inventions provides improved rheological characteristics of liquid preparation, particularly high viscosity and reduced dependence on temperature.

4 cl, 5 ex