FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to agents stimulating natural (natural) killer (NK) cells, and can be used in medicine for treating cancer, as well as to inhibit acute or chronic graft-versus-host disease, virus reactivation and opportunistic infections. Disclosed is a composition containing a feeder cell designed for expression of a fused protein, containing membrane-bound inverted domain Fc, IL-21 and 4-1BBL, or a plasma membrane particle (PM) obtained from said feeder cell or an exosome. Fused protein contains a transmembrane domain bound to the amino-terminal of the membrane-bound inverted Fc domain and is configured to bind the amino-terminal of the inverted Fc domain to the outer surface of the engineered feeder cell, PM particle or exosome.
EFFECT: invention enables to increase the number and cytotoxicity of NK cells, which provides a therapeutic effect.
24 cl, 8 dwg, 5 ex
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