FIELD: medicine.
SUBSTANCE: present invention relates to transmucosal therapeutic systems for transmucosal administration of agomelatine, having a mucoadhesive layered structure containing a therapeutically effective amount of agomelatine, such agomelatine-based transmucosal therapeutic systems for use in a method of treatment, comprising the use of such agomelatine-based transmucosal therapeutic systems, and methods of making such transmucosal therapeutic systems.
EFFECT: preferential penetration and release of agomelatine.
15 cl, 21 dwg, 11 tbl
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