FIELD: biotechnology.
SUBSTANCE: present invention provides effective methods and compositions for delivering messenger RNA (mRNA) by rectal delivery.
EFFECT: present invention is based in part on the unexpected observation that mRNA can be efficiently delivered to the blood circulation, liver, kidney, colon and/or rectum by rectal delivery despite barriers such as RNase and mucus layer.
26 cl, 10 dwg, 5 ex
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