FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and molecular biology. Disclosed is an improved method of forming lipid nanoparticles and encapsulating mRNA, comprising a step of heating lipid nanoparticles with encapsulated mRNA in a solution to formulate a medicinal product.
EFFECT: invention is applicable for providing a higher degree or efficiency of encapsulation when producing mRNA-LNP compared to traditional approaches.
27 cl, 5 dwg, 3 tbl, 3 ex
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