FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and can be used for making bone screws for internal fixation of fracture. Method of producing a composite material based on silk fibroin/hydroxyapatite involves holding a homogeneous mixture of nanoparticles of hydroxyapatite, silk fibroin and hexafluoroisopropanol in a temperature range of 50 °C to 60 °C for at least 3 hours to obtain a viscous solution of silk fibroin/hydroxyapatite, which is poured into a long cylindrical mould, wherein the two ends of the long cylindrical shape are end A and end B. Then, at room temperature, leaving end A open and end B closed, the mould with the open hole facing upwards is dipped vertically into methanol and the mould is left to settle for at least 2 days. After that, the mould is turned upside down, while leaving the end A closed and the end B open, vertical immersion of the mould with the open hole facing upwards into methanol and leaving the mould for settling for at least 2 days. Then the mould is removed and performing ventilation and drying to obtain a composite material based on silk fibroin/hydroxyapatite. Also disclosed is a composite material obtained using said method and having regular pores with diameter of 2 mcm to 10 mcm, and use of the composite material for making articles for bone repair.
EFFECT: obtained composite material is characterized by the presence of ordered internal pores of regular shape and uniform distribution of hydroxyapatite, homogeneous strength, good mechanical properties and considerable osteoinduction, which enables to use it for making large-size bone screws up to 150 mm long, having maximum deforming load in three-point bending test 171.73 N and tensile strength 112.2 MPa.
10 cl, 7 dwg, 1 tbl
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Authors
Dates
2025-05-21—Published
2022-03-09—Filed