FIELD: medicine.
SUBSTANCE: invention refers to a composition of a vaccine for immunization and protection by way of prevention or metaphylaxis in pigs against pleuropneumonia caused by Actinobacillus pleuropneumoniae, containing modified polypeptides ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae. Also disclosed is the use of said vaccine composition for the preparation of a drug for immunization and protection by preventing or metaphylaxis of pigs from pleuropneumonia caused by Actinobacillus pleuropneumoniae, to obtain a humoral and/or cell-mediated immunological response, wherein the vaccine composition is configured to be administered intramuscularly, intracutaneously, intravenously, subcutaneously or by mucosal application.
EFFECT: invention provides effective immunization and protection of pigs against pleuropneumonia caused by Actinobacillus pleuropneumoniae.
14 cl, 10 dwg, 12 tbl, 16 ex
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