METHOD FOR SIMULATING BRAIN ACTIVITY OF A PATIENT WITH EPILEPSY Russian patent published in 2025 - IPC G16H50/00 

FIELD: medical science.

SUBSTANCE: invention refers to medical diagnostics and medical modelling, namely to a method for simulating brain activity of a patient with epilepsy for the purpose of determining a dynamics of onset, distribution and attenuation of epileptic seizures in a brain model of the patient. What is presented is a method for simulating the cerebral activity of a patient with epilepsy with using the modular model of the patient’s brain that involves: obtaining a regional sub-model of the patient's brain based on the structure of the patient's brain, in which interactions between the patient's brain regions are determined, taking into account data on the dynamics of biophysical processes occurring in nerve cells of the brain regions of the patient coming from the cellular sub-models; in cellular sub-models, determining the dynamics of biophysical processes occurring in the nerve cells of the patient's brain regions, taking into account data on the dynamics of movements of AMPA receptors coming from the receptor sub-models, and transmitting these data to the regional sub-model; in receptor sub-models, determining the dynamics of movements of AMPA receptors in dendritic spines of nerve cells of the patient's brain and transmitting these data to cellular sub-models; determining the dynamics of the onset, distribution and attenuation of epileptic seizures in the patient's brain model.

EFFECT: invention provides constructing the modular multilevel brain model including interconnected regional, cell and receptor submodels.

14 cl, 5 dwg