FIELD: chemistry; medicine.
SUBSTANCE: invention relates to biochemistry, immunology and medicine, in particular to polypeptides containing an antigen-binding domain and a transporting fragment having an inhibitory domain, which inhibits the antigen-binding activity of the antigen-binding domain and has a longer half-life compared to the antigen-binding domain in its individual form, a method of producing polypeptides, pharmaceutical compositions containing a polypeptide.
EFFECT: disclosed polypeptides enable to provide recovery of antigen-binding domain of its antigen-binding activity in diseased tissues and manifestation of antigen-binding activity in diseased tissues.
14 cl, 31 dwg, 23 tbl, 16 ex
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