FIELD: biotechnology.
SUBSTANCE: invention discloses an antibody against properdin or an antigen-binding portion thereof and an immunoconjugate containing them. Also disclosed is a composition containing said antibody or antigen-binding portion thereof. Invention also relates to a nucleic acid coding said antibody, an expression vector and a host cell containing said nucleic acid. Antibody can be used to prepare a drug for treating diseases mediated by a component of the alternative complement pathway and/or a factor formed after activation of the alternative complement pathway.
EFFECT: antibody of the present invention leads to selective inhibition of the alternative complement pathway, while allowing the classical and lectin pathways to be continued.
18 cl, 10 dwg, 8 tbl, 19 ex
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