PROPERDIN ANTIBODIES AND PRODUCTION THEREOF Russian patent published in 2024 - IPC C07K16/18 C12N15/13 C12N15/63 A61K39/395 

Abstract RU 2830308 C1

FIELD: biotechnology.

SUBSTANCE: invention discloses an antibody against properdin or an antigen-binding portion thereof and an immunoconjugate containing them. Also disclosed is a composition containing said antibody or antigen-binding portion thereof. Invention also relates to a nucleic acid coding said antibody, an expression vector and a host cell containing said nucleic acid. Antibody can be used to prepare a drug for treating diseases mediated by a component of the alternative complement pathway and/or a factor formed after activation of the alternative complement pathway.

EFFECT: antibody of the present invention leads to selective inhibition of the alternative complement pathway, while allowing the classical and lectin pathways to be continued.

18 cl, 10 dwg, 8 tbl, 19 ex

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RU 2 830 308 C1

Authors

Mendiratta, Sanjeev Kumar

Singh, Arun

Kasera, Ramkrashan

Parikh, Aashini

Upadhyay, Jimit

Kalita, Pankaj

Bandyopadhyay, Dilip

Shah, Ashu

Dates

2024-11-18Published

2021-01-08Filed