FIELD: biotechnology; medicine.
SUBSTANCE: present invention relates to medical biotechnology, namely to antigen-based immunotherapy, particularly to cancer immunotherapy. Disclosed is an antigenic peptide for treating a B-cell malignant tumour, consisting of an amino acid sequence presented in SEQ ID NO 65; immunogenic compound for treating a B-cell malignant tumour containing said antigenic peptide. Disclosed is an antigen-presenting cell for treating a B-cell malignant tumour, where antigen-presenting cell is loaded with said antigen peptide or immunogenic compound; nucleic acid coding an antigenic peptide, an immunogenic compound, where the immunogenic compound is a peptide or protein. Disclosed are a pharmaceutical composition and a combination for treating a B-cell malignant tumour; use of the antigenic peptide for treating a B-cell malignant tumour; method of treating a B-cell malignant tumour in a subject in need thereof, and a multimer peptide-MHC (pMHC) for detecting antigen-specific T-cells.
EFFECT: disclosed antigenic peptide can be used to induce a specific immune response against known tumor antigens.
20 cl, 25 dwg, 7 tbl, 4 ex
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