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1 047 159

(13)

A1

(51)

IPC

(21) (22)

Application

3370684/05, 1981-12-15

(22)

Actual filing date

1981-12-15

(45)

Published

1998-01-10

(72)

Inventor

Plateh N.A.Chupov V.V.Volkov A.V.Valuev L.I.Chupova L.A.

METHOD OF PRODUCING THE POLYMERIC ADSORBENT FOR ISOLATION AND PURIFICATION OF SERUM ALBUMIN Russian patent published in 1998 - IPC

Abstract SU 1047159 A1

FIELD: biotechnology, sorbents. SUBSTANCE: method involves the radical triple copolymerization of hydrophilic vinyl monomer forming gel matrix, bifunctional monomer-cross-linking agent and comonomer-ligand in an aqueous solution in the presence of initiating agent of radical type. (Meth)acryloyl derivative of L-lysine of the general formula is used as a comonomer-ligand. Copolymerization is carried out at the following ratio of reaction mixture components, weight%: hydrophilic vinyl monomer 4.5-17.5; bifunctional monomer-cross-linking agent 0.5-7.5; comonomer-ligand indicated above 0.1-2.5, and water - up to 100. The obtained copolymer is treated with copper (II) or zinc (II) salt solutions at concentration 1 mg/ml up to its complete saturation. Alternative method involves the use of acrylamide or N-vinylpyrrolidone as hydrophilic vinyl monomer. Alternative method involves the use of N,N-methylene-bis-acrylamide or methacrylic acid and ethylene glycol diester as a bifunctional monomer-cross-linking agent. EFFECT: improved purity degree of serum albumin, increased stability of adsorbent.

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SU 1 047 159 A1

Authors

Plateh N.A.

Chupov V.V.

Volkov A.V.

Valuev L.I.

Chupova L.A.

Dates

1998-01-10—Published

1981-12-15—Filed

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