METHOD OF HEME-COMPATIBLE POLYMERIC HYDROGEL PRODUCING Russian patent published in 1998 - IPC

Abstract SU 1287541 A1

FIELD: medicine, polymers. SUBSTANCE: method involves the radical copolymerization of hydrophilic monomer and bifunctional monomer-cross-linking agent in an aqueous solution in the presence of trypsin acylated with acrylic or methacrylic acid chloroanhydride. A mixture of 98-99 wt.-% acrylamide and 1-2 wt. -% ±-methacryloyl-L-lysine is used as hydrophilic monomer. Method ensures to increase fibrinolytic activity of polymeric hydrogels and blood coagulation time to 31 ± 2 - 34 ± 3 mcg tyrosine/min/1 ml gel and 126 ± 3 - 134 Nε 3 min, respectively. Hydrogel can be used for making articles contacting with blood. EFFECT: improved method of producing, improved quality and property of hydrogels. 1 tbl

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SU 1 287 541 A1

Authors

Plateh N.A.

Chupov V.V.

Valuev L.I.

Dates

1998-01-10Published

1985-04-16Filed