FIELD: medicine, polymers. SUBSTANCE: method involves the radical copolymerization of hydrophilic monomer and bifunctional monomer-cross-linking agent in an aqueous solution in the presence of trypsin acylated with acrylic or methacrylic acid chloroanhydride. A mixture of 98-99 wt.-% acrylamide and 1-2 wt. -% ±-methacryloyl-L-lysine is used as hydrophilic monomer. Method ensures to increase fibrinolytic activity of polymeric hydrogels and blood coagulation time to 31 ± 2 - 34 ± 3 mcg tyrosine/min/1 ml gel and 126 ± 3 - 134 Nε 3 min, respectively. Hydrogel can be used for making articles contacting with blood. EFFECT: improved method of producing, improved quality and property of hydrogels. 1 tbl
Title | Year | Author | Number |
---|---|---|---|
METHOD OF HEME-COMPATIBLE POLYMERIC HYDROGEL PRODUCING | 1982 |
|
SU1078894A1 |
METHOD OF PREPARING POLYMERIC ADSORBENT FOR ISOLATION OF PROFIBRINOLYSIN FROM PLASMA BLOOD | 1988 |
|
SU1508548A1 |
METHOD OF PRODUCING THROMBORESISTANT POLYMER MATERIALS | 2009 |
|
RU2405002C1 |
BIOSPECIFIC POLYMER ADSORBENT FOR EXTRACTING PROTEINASE (ITS VERSIONS) | 0 |
|
SU1137388A1 |
METHOD OF PREPARING THROMBORESISTANT POLYMERIC MATERIALS | 0 |
|
SU665639A1 |
AFFINE ADSORBENT FOR REMOVAL OF BILIRUBIN AND OTHER TOXICANTS FROM BLOOD AND A METHOD OF ITS PRODUCING | 1978 |
|
SU731752A1 |
METHOD OF PREPARING THROMBORESISTANT POLYMERIC MATERIALS | 0 |
|
SU666815A1 |
AFFINE ADSORBENT FOR REMOVAL OF BILIRUBIN AND OTHER TOXICANTS FROM BLOOD AND A METHOD OF ITS PRODUCING | 1978 |
|
SU731750A1 |
METHOD OF PRODUCING THE POLYMERIC ADSORBENT FOR ISOLATION AND PURIFICATION OF PROFIBRINOLYSIN | 1987 |
|
SU1462756A1 |
METHOD OF PRODUCING BIOSPECIFIC POLYMER SORBENT FOR EXTRACTING PROTEINASE | 2010 |
|
RU2420739C1 |
Authors
Dates
1998-01-10—Published
1985-04-16—Filed