METHOD OF SYNTHESIS OF DERIVATIVES OF $$$-(2,4-DICHLORO-5-NITROBENZOYL)-$$$-AMINOACRYLIC ACID Russian patent published in 1997 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: product: derivatives of $$$-(2,4-dichloro-5-nitrobenzoyl)-$$$-aminoacrylic acid of the general formula (I) R-NH-CH=CK-C(O)M where: K - C(O)O-$$$; M - 2,4-dichloro-5-nitrophenyl; R - $$$, iso-$$$, $$$, p-Cl-$$$, p-F-$$$. Synthesis is carried out from $$$-(2,4-dichloro-5-nitrobenzoyl)-$$$-ethoxyacrylic acid ethyl ether and amine of the general formula (II) R-$$$ where R - as indicated above in medium of inert organic solvent, at temperature from -10 to +20 C. Method ensures to obtain new derivatives of (I) that contain chlorine atoms and nitro-group as substituents in aromatic ring providing increase of reactive activity. Synthesized compounds can be used for synthesis of biologically active compounds. EFFECT: improved new method of synthesis. 1 tbl