3-CARBALKOXYAMINO-5-(ω-AMINOACYL)-5H-DIBENZ (b,f) AZEPINES HAVING ANTIARYTHMIC ACTIVITY Russian patent published in 1997 - IPC

Abstract RU 2092480 C1

FIELD: medicine. SUBSTANCE: present invention describes 3-carbalkoxy amino-5 (w-aminoacyl)-5H-dibenz (b,f) azepines, more particularly compounds of general formula: wherein Y is -C(O)-(CH2)m-NHR2•(HCl)n; X is -(CH2)2-; (a) R1=R2=CH3; m=n=1 or m=2 and n= 1; (b) R1= CH3, R2= C2H5; m=n=1; (c) C2H4OH; R1= C2H5; m=1, n=0 or 1 ; (d) R2= H or CH3; m=1, n=0 or 1; R1= R2= C2H5; m=1, n=0 or 1; (e) R1= C2H5, R2= n-C3H7; n-C4H9, cyclohexyl, R1= C2H5, m=n=1; (f) R2= n-C6H13; n-C4H9; R1= C2H5, m=n=1 or m=2, n=1; R2= C2H4OH; R1= iso-C3H7 or R2= C2H5, m= 1, n=0 or 1; (g) tets-C4H9, m=1, n=0 or 1; (h) R1= C2H4OH; R1= iso-C3H7, m=1, n=0; (i) R2= CH3; R1= R2= C2H5, m=1; (j) R2= C6H5(CH2)2; R1= C2H5, m=1, n= 0 or 1; (k) R2= CH3, m=n=1, which have antiarythmic activity and are useful in medicine. Synthesis is carried out by reacting alkyl amino with 3- carbalkoxyamino-5-chloroacyl-10, 11-dihydro-5H-dibenz (b, f) azepine in solvent at boiling temperature. As compared with bonecor, novel agents are more active and less toxic. EFFECT: improved properties of the title compounds. 1 tbl

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Authors

Skoldinov Aleksandr Petrovich[Ru]

Kaverina Natalija Ven'Jaminovna[Ru]

Gritsenko Anna Nikitichna[Ru]

Lyskovtsev Valentin Viktorovich[Ru]

Rodionov Aleksandr Petrovich[Ru]

Grigor'Eva Ekaterina Klement'Evna[Ru]

Vunderlikh Khel'Mut[De]

Shtark Andreas[De]

Lomann Diter[De]

Tsenker Lotar[De]

Barch Reni[De]

Poppe Khil'Degard[De]

Dates

1997-10-10Published

1989-07-13Filed