FIELD: medicine, organic chemistry. SUBSTANCE: bromobenzoin and ammonium thiocyanate are boiled together in the medium of dioxane. Thus prepared 4-bromophenyl-2-mercapto-5-phenyl imidazole is then reacted with hydrobromide of 2-morpholinoethyl bromide. The process takes place in the presence of NaOH in the medium of aqueous alcohol. Thus obtained base is then converted into hydrochloride by its treatment with HCl. Melting point of desired product is 221 C, its toxicity is 638 mg/kg. EFFECT: improves quality of desired product.
| Title |
Year |
Author |
Number |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-4-PHENYL IMIDAZOLE WHICH INCREASES PHYSICAL RESISTANCE AT THERMAL STRESS |
1986 |
- Tomchin A.B.
- Vinogradov V.M.
- Sumina Eh.N.
- Petushkov N.M.
|
SU1356420A1 |
| 4-(4'-METHOXYPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYLIMIDAZOLE DIHYDROCHLORIDE ENHANCING PHYSICAL RESISTANCE |
1986 |
- Vinogradov V.M.
- Tomchin A.B.
- Spivakova R.P.
- Katkov V.F.
|
SU1415725A1 |
| DICHLORIDE OF 2-ALLYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING STRESS PROTECTING ACTIVITY AND ACCELERATES PROCESSES OF RECOVERY AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
|
SU1327497A1 |
| DIHYDROCHLORIDE OF 4,5-DI-(3′,4′-DIMETHOXYPHENYL)-2-MORPHOLINOETHYLTHIO IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1295709A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINOETHYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA AND ACCELERATING PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Basieva T.S.
- Smirnov A.V.
- Bobkov Ju.G.
- Lozinskij M.O.
- Katkova E.B.
|
SU1220306A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINO-ETHYLTHIO-4,5-DI-(P-CHLOROPHENYL)IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
|
SU1279212A1 |
| HYDROCHLORIDE OF 5,6-DIPHENYL-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINE HAVING PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Katkova E.B.
|
SU1216966A1 |
| DIHYDROCHLORIDE OF MONOHYDRATE OF 8-BROMO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO/5,6-B/INDOLE HAVING PROTECTING ACTIVITY AGAINST STRESS AND INCREASING PHYSICAL RESISTANCE |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Smirnov A.V.
- Katkova E.B.
- Lozinskij M.O.
- Bobkov Ju.G.
|
SU1220301A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| 3-(2-DIETHYLAMINOETHYLTHIO)-5-(2-MORPHOLINOETHYL)-1,2,4- TRIAZINO(5,6-b)INDOL DIHYDROCHLORIDE POSSESSING STRESS-PROTECTIVE ACTIVITY |
1982 |
- Vinogradov V.M.
- Tomchin A.B.
- Katkova E.B.
- Katkov V.F.
|
SU1154907A1 |
