FIELD: medicine, organic chemistry. SUBSTANCE: desired product is prepared by interaction of thiocynate of NH4 and dioxane. The process is carried out by boiling, it is followed by treatment with hydrobromide of 2-morpholinoethyl bromide. The latter process takes place in aqueous-alcohol medium in the presence of NaOH. Thus obtained base is converted into hydrochloride with the help of concentrated HCl. Thus prepared oil is ground with isopropanol and then desired product is separated. Its yield is 46.1 %. Melting point of desired product is 230 C, its toxicity being 932 mg/kg. EFFECT: improves quality of desired product. 1 tbl
| Title |
Year |
Author |
Number |
| DIHYDROCHLORIDE OF 2-MORPHOLINO-ETHYLTHIO-4,5-DI-(P-CHLOROPHENYL)IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
|
SU1279212A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINOETHYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA AND ACCELERATING PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Basieva T.S.
- Smirnov A.V.
- Bobkov Ju.G.
- Lozinskij M.O.
- Katkova E.B.
|
SU1220306A1 |
| DIHYDROCHLORIDE OF 4-(4′-BROMOPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYL IMIDAZOLE HAVING PROTECTING ACTIVITY AGAINST STRESS |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1387374A1 |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-4-PHENYL IMIDAZOLE WHICH INCREASES PHYSICAL RESISTANCE AT THERMAL STRESS |
1986 |
- Tomchin A.B.
- Vinogradov V.M.
- Sumina Eh.N.
- Petushkov N.M.
|
SU1356420A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| DICHLORIDE OF 2-ALLYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING STRESS PROTECTING ACTIVITY AND ACCELERATES PROCESSES OF RECOVERY AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
|
SU1327497A1 |
| 8-METHOXY-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]- INDOLE MALATE SHOWING ANTIHYPOXIC ACTIVITY |
1988 |
- Tomchin A.B.
- Marysheva V.V.
- Katkov V.F.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1547280A1 |
| 4-(4'-METHOXYPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYLIMIDAZOLE DIHYDROCHLORIDE ENHANCING PHYSICAL RESISTANCE |
1986 |
- Vinogradov V.M.
- Tomchin A.B.
- Spivakova R.P.
- Katkov V.F.
|
SU1415725A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-5-ETHOXYBENZIMIDAZOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Dmitrukha V.S.
- Vinogradov V.M.
- Spivakova R.P.
- Katkov V.F.
- Bobkov Ju.G.
|
SU1262926A1 |
