FIELD: organic chemistry, imidazole derivatives. SUBSTANCE: product: 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole. Synthesis is carried out by reaction of 2-mercapto-4-(4'-methoxyphenyl)-5-phenylimidazole with 2-morpholinoethyl bromide hydrobromide followed by conversion of obtained base to hydrochloride by treatment with HCl. Yield is 92%, m. p. is 155 C, empirical formula is C22H29Cl2N3O3S.. Synthesized compound provides the best resistance at run as compared with control after 24 hr to 188%, toxicity LD50 = 575 mg/kg. EFFECT: synthesis of new substances showing enhanced activity. 1 tbl
| Title |
Year |
Author |
Number |
| DIHYDROCHLORIDE OF MONOHYDRATE OF 8-BROMO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO/5,6-B/INDOLE HAVING PROTECTING ACTIVITY AGAINST STRESS AND INCREASING PHYSICAL RESISTANCE |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Smirnov A.V.
- Katkova E.B.
- Lozinskij M.O.
- Bobkov Ju.G.
|
SU1220301A1 |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-4-PHENYL IMIDAZOLE WHICH INCREASES PHYSICAL RESISTANCE AT THERMAL STRESS |
1986 |
- Tomchin A.B.
- Vinogradov V.M.
- Sumina Eh.N.
- Petushkov N.M.
|
SU1356420A1 |
| DIHYDROCHLORIDE OF 2-(2-MORPHOLINOETHYLTHIO)-5-ETHOXYBENZIMIDAZOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Dmitrukha V.S.
- Vinogradov V.M.
- Spivakova R.P.
- Katkov V.F.
- Bobkov Ju.G.
|
SU1262926A1 |
| DIHYDROCHLORIDE OF 4-(4′-BROMOPHENYL)-2-MORPHOLINOETHYLTHIO-5-PHENYL IMIDAZOLE HAVING PROTECTING ACTIVITY AGAINST STRESS |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1387374A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINOETHYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA AND ACCELERATING PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Basieva T.S.
- Smirnov A.V.
- Bobkov Ju.G.
- Lozinskij M.O.
- Katkova E.B.
|
SU1220306A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINO-ETHYLTHIO-4,5-DI-(P-CHLOROPHENYL)IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
|
SU1279212A1 |
| DICHLORIDE OF 2-ALLYLTHIO-4,5-DIPHENYL IMIDAZOLE HAVING STRESS PROTECTING ACTIVITY AND ACCELERATES PROCESSES OF RECOVERY AFTER PHYSICAL LOAD |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
|
SU1327497A1 |
| DIHYDROCHLORIDE OF 4,5-DI-(3′,4′-DIMETHOXYPHENYL)-2-MORPHOLINOETHYLTHIO IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
- Katkova E.B.
|
SU1295709A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
