1-AMINONAPHTHALENE-5-SULFAMIDES AS REAGENTS FOR ENZYME SUBSTRATE ASSAY Russian patent published in 1994 - IPC

Abstract SU 1419108 A3

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out, for example, from 1-(N-benzylhydroxycarbonyl)-aminonaphthalene-5-(N′, N′-pentamethylene)sulfamide, which is converted to tribromohydrate with HBr. The latter is transformed to the base by treatment with aqueous-isopropanol soda solution. Yield is up to 55% . New substances are oxidized gradually in the air with formation of colored products. In solution new substances show bright-yellow fluorescence (wavelength λ_max ~525 mm is near 525 nm). Sensitivity of detected enzyme groups assay is improved up to 250-800% . EFFECT: enhanced sensitivity of assay. 3 tbl

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SU 1 419 108 A3

Authors

Nedospasov A.A.

Dates

1994-03-15—Published

1985-06-28—Filed