5-(N-CARBOBENZOXY)AMINONAPHTHALENE-1-SULFONATE SODIUM AS A SEMIPRODUCT FOR SYNTHESIS OF SUBSTITUTED 5-AMINONAPHTHALENE-1-SULFAMIDES USED AS ENZYME SUBSTRATE DETECTABLE GROUPS Russian patent published in 1994 - IPC

Abstract SU 1419107 A3

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from 5-aminonaphthalene-1-sulfoacid Na₂CO₃ and 50% aqueous solution of carbobenzoxychloride in aqueous-toluene medium at cooling. Yield is 85% , m. p. is 260 C (with decomposition), gross-formula is C₁₈H₄NO₅SNa. Improvement of sensitivity of assay of detectable group in enzyme substrate is 400% as compared with use of 1-aminonaphthalene-5-sulfoacid as a substrate. EFFECT: enhanced sensitivity of assay.

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SU 1 419 107 A3

Authors

Nedospasov A.A.

Dates

1994-03-15—Published

1985-06-28—Filed