FIELD: organic chemistry. SUBSTANCE: derivatives of triazole, in part, 1,4-diglycidyl-3-ethyl-1,2,4-triazole-5-one. Synthesis is carried out from 3-ethyl-1,2,4-triazole-5-one and epichlorohydrin in the presence of an aqueous alkali for 5 h. Yield is 40%, m. p. is 41-45 C, empirical formula is C10H15N3O3.. Toxicity of new compound by 4-5-fold less as compared with 1,2,4-triglycidylurazole. New compound inhibits growth of Jensen sarcoma, sarcoma M-1, Walker carcinosarcoma and melanoma B-16 by 93; 97; 99.7 and 94% as compared with 65; 20; 59 and 48%, respectively. EFFECT: enhanced antitumor activity of compound, decreased toxicity. 2 tbl
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Year |
Author |
Number |
| 1,1'-DIGLYCIDYL-3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)- -METHANE SHOWING ANTITUMOR ACTIVITY AND 3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)-METHANE AS AN INTERMEDIATE COMPOUND FOR SYNTHESIS OF 1,1'-DIGLYCIDYL-3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)- -METHANE |
1989 |
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| 1,3-DIGLYCIDYL-2,4-QUINAZOLINEDIONE SHOWING ANTITUMOR ACTIVITY |
1988 |
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| ISOTHIURONIUM AZINES SHOWING ANTITUMORAL ACTIVITY |
1991 |
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1982 |
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| DIHYDROCHLORIDE 1-(3-NITRO-4- METHOXYBENZENE)-2- [BIS-(2- CHLORETHYL) AMINOMETHYL]IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY |
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| 5-BENZIL-11,13-DIMETHHYL-2,8,12-TRIOXO-1,5,9-TRIAZACYCLO [9,3,1,1] HEXADECANE, POSSESSING ANTITUMOR ACTIVITY |
1985 |
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| ETHYL ESTER OF CIS-4-N-(N',N'-DIMETHYLAMIDO-N''-ETHYLENEIMIDOPHOSPHORYL)- AMINOCIC- LOCARBOXYLIC ACID HAVING ANTITUMORAL ACTIVITY |
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1991 |
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