FIELD: heterocyclic compounds. SUBSTANCE: product: 1,3-diglycidyl-2,4-quinazolinedione. Synthesis is carried out from urea and anthranilic acid. 2,4-Quinazolinedione synthesized at the first stage is subjected for interaction with epichlorohydrin and condensation products were dehydrochlorinated with alkali. The yield is 58-82%; LD50 = 280 mg/kg. Synthesized compound shows antitumor activity. EFFECT: increased yield. 3 tbl
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Year |
Author |
Number |
| 1,4-DIGLYCIDYL-3-ETHYL-1,2,4-TRIAZOLE-5-ONE SHOWING ANTITUMOR ACTIVITY |
1989 |
- Losev G.A.
- Korotkikh N.I.
- Chernov V.A.
- Shvajka O.P.
- Popov S.A.
|
SU1651525A1 |
| 1,1'-DIGLYCIDYL-3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)- -METHANE SHOWING ANTITUMOR ACTIVITY AND 3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)-METHANE AS AN INTERMEDIATE COMPOUND FOR SYNTHESIS OF 1,1'-DIGLYCIDYL-3,3'-DIETHYLBIS-(1,2,4-TRIAZOLE-5-ONE-4-YL)- -METHANE |
1989 |
- Korotkikh N.I.
- Losev G.A.
- Chernov V.A.
- Shvajka O.P.
- Popov S.A.
|
SU1658606A1 |
| ISOTHIURONIUM AZINES SHOWING ANTITUMORAL ACTIVITY |
1991 |
- Losev Georgij Alekseevich[Ua]
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- Shvajka Oles' Pavlovich[Ua]
|
RU2032676C1 |
| 3-PHENYL-10H-4,5-DIHYDROPYRAZOLO[4,3-A]CARBAZOLE SHOWING ANTITUMOR AND ANTILEUKEMIC ACTIVITY |
1991 |
- Sokolova A.S.
- Bogomolova N.S.
- Romanova O.B.
- Granik V.G.
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RU2007394C1 |
| 5,7-O-BIS-(DIETHYLAMINOETHYL)-USNINIC ACID DITARTRATE SHOWING ANTITUMOR ACTIVITY |
1991 |
- Artamonova N.A.
- Nikonov G.K.
- Rakhimov K.D.
|
RU1782009C |
| ETHYL ESTER OF CIS-4-N-(N',N'-DIMETHYLAMIDO-N''-ETHYLENEIMIDOPHOSPHORYL)- AMINOCIC- LOCARBOXYLIC ACID HAVING ANTITUMORAL ACTIVITY |
1985 |
- Pikshilingajte Ju.-V.K.
- Kosykhova L.A.
- Ljutkene R.G.
- Karpavichjus K.I.
|
SU1282520A1 |
| 5-BENZIL-11,13-DIMETHHYL-2,8,12-TRIOXO-1,5,9-TRIAZACYCLO [9,3,1,1] HEXADECANE, POSSESSING ANTITUMOR ACTIVITY |
1985 |
- Agadzhanjan Ts.E.
- Arutjunjan G.L.
- Garibdzhanjan B.T.
- Chachojan A.A.
|
SU1285754A1 |
| 4(5)-(3-NITRO-4-(3,3-DIMETHYLTRIAZENO-1)PHENYL)IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY |
1982 |
- Iradjan M.A.
- Iradjan N.S.
- Stepanjan G.M.
- Arsenjan F.G.
- Garibdzhanjan B.T.
|
SU1074091A1 |
| DIHYDROCHLORIDE 1-(3-NITRO-4- METHOXYBENZENE)-2- [BIS-(2- CHLORETHYL) AMINOMETHYL]IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY |
1981 |
- Iradjan M.A.
- Iradjan N.S.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU976654A1 |
| 2,2-DIMETHYL-1,2-DIHYDRO-5-(N-MORPHOLINE)-8-CHLOR OR PHENYLHYDRAZINO-4H-PIRANO[4′,3′:4,5]PYRIDO[2,3-B]THIENO[3,2-D]-9,10,11-TRIAZINES HAVING ANTITUMOR ACTION |
1988 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1570274A1 |
