FIELD: medicine. SUBSTANCE: the synthesis is carried out by reacting p-oxycinnamic acid and α-bromocaproic acid in the presence of sodium hydroxy on heating. The field 80%, mp 190-191 C, the empirical formula C15H18O5. As compared with the activity of 4-carboxymethylenoxycinnamic acid and papaverine hydrochloride, the hypotensive activity of the new compound (after 60 min) is higher by 1.7 and 2.6 times. The toxicity LD50>3000 mg/kg is similar to the toxicity of the structural analogue, but less than LD50 of papaverine hydrochloride (500 mg/kg). EFFECT: new and more active compounds of said class. 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 4-CARBOXYMETHYLENOXYCINNAMIC ACID POSSESSING HYPOTENSION ACTIVITY | 0 |
|
SU1446712A1 |
| 1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY | 2006 |
|
RU2320661C2 |
| 1-(3,4-DIETHOXYPHENYL)-2,3,5,6-TETRAHYDRO-(3,4-DIETHOXYBENZO) [g]QUINOXALINO[2,3-b]INDOLIZINE HYDROCHLORIDE OF DIRECT ANTICOAGULATION EFFECT | 2006 |
|
RU2330850C1 |
| 1-(ISOFLAVONYL-7-OXYCARBONYLVINYL)-4- (ISOFLAVONYL-7-OXYCARBONYLMETHYLENOXY) BENZENE HAVING HYPOTENSIVE AND HYPOLIPIDEMIC ACTIVITIES | 1988 |
|
SU1531431A1 |
| N-BENZYLAMIDE 2-(3-METHYL-6-METHOXY-7-ETHOXY-3,4-DIHYDROISOQUINOLYL-1)-ETHANIC ACID HYDROCHLORIDE, DEMONSTRATING INSECTICIDAL ACTIVITY | 2012 |
|
RU2529504C2 |
| N-(2-METHYLPHENOXYETHYL)-N-CYCLOHEXYLAMINE HYDROCHLORIDE POSSESSING HYPOTENSIVE ACTIVITY | 2005 |
|
RU2303026C1 |
| 2,2-DIMETHYL-4-(4,6-DIMETHYL-2-PYRIDON-3-YL)-1,2-DIHYDROBENZO[f]ISOQUINOLINE HYDROCHLORIDE ELECTING DIRECT ANTICOAGULANT EFFECT | 2006 |
|
RU2320654C1 |
| 1-BENZYL-6-METHOXY-3-METHYL-1H-1,2-DIAZAPHENALENE HAVING HYPOTENSIVE ACTIVITY | 1989 |
|
SU1623143A1 |
| 4-IMINOCHROMEN DERIVATIVES HAVING ANTIHYPOXIC, HYPOTENSIVE AND ANTILALLERGIC ACTIVITIES | 1990 |
|
SU1746675A1 |
| HYPOTENSIVE N-2-(2'-METHYLPHENOXY)-ETHYLMORPHOLINE HYDROCHLORIDE | 2007 |
|
RU2354652C2 |
