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Application

4854367/04, 1990-07-20

(22)

Actual filing date

1990-07-20

(45)

Published

1994-09-30

(72)

Inventor

Оganesjan Еh.Т.Ivchenko А.V.Ivashev М.N.Lysenko Т.А.Saraf А.S.

4-IMINOCHROMEN DERIVATIVES HAVING ANTIHYPOXIC, HYPOTENSIVE AND ANTILALLERGIC ACTIVITIES Russian patent published in 1994 - IPC

Abstract SU 1746675 A1

FIELD: 4-iminochromen derivatives, more particularly compounds of the formula: , where R1=OH; R2=C(O)CH3; R3=(CH2)2-C(O)-OH; R4=H and R5=OCH3 or R4=OH; R2=C(O)-CH3;; R3=(CH2)5-C(O)OH; R4=OCH3 and R5=OH having antihypoxic, hypotensive and antiallergic activities and can be used in medicine. SUBSTANCE: the synthesis is effected by condensation of 4-ethoxyflavilium perchlorate with the corresponding alkanic acids containing an amino group in an acid medium. The yield 58-63% , mp 169-170 C for the empirical formula: C21H19NO6 and mp 260-270 C for the empirical formula: C24H25NO7. The toxicity LD50 greater than 1010 mg/kg. EFFECT: new compounds of said class having, in addition to antiallergic activity, also antihypoxic and hypotensive activities. 3 tbl

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SU 1 746 675 A1

Authors

Оganesjan Еh.Т.

Ivchenko А.V.

Ivashev М.N.

Lysenko Т.А.

Saraf А.S.

Dates

1994-09-30—Published

1990-07-20—Filed

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