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1 648 054

(13)

A3

(51)

IPC

(21) (22)

Application

4326078/04, 1987-04-17

(22)

Actual filing date

1987-04-17

(45)

Published

1994-03-15

(72)

Inventor

Nedospasov A.A.Moguchaja G.Ju.

(73)

Holder

Institut Molekuljarnoj Genetiki Ran

METHOD OF SUBSTITUTED 1-AMINONAPHTHALENE-5-SULFAMIDES SYNTHESIS Russian patent published in 1994 - IPC

Abstract SU 1648054 A3

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from 1-aminonaphthalene-5-sulfoacid and triethylamine by acylation of prepared salt with trifluoroacetic anhydride in the medium of trifluoroacetic acid or diethyl ether following by treatment with phosphorus pentachloride and sulfochloride is obtained. The latter is aminated in organic solvent: ethylacetate, acetone, acetonitrile, and 1-trifluoroacetylaminonaphthalene-5-sulfamide is obtained. The protective group is removed with ammonia in aqueous ethanol or in isopropanol; or amination and protective group removal in aqueous solution of corresponding amine are carried out. EFFECT: enhanced yield, enlarged assortment of products. 5 tbl

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SU 1 648 054 A3

Authors

Nedospasov A.A.

Moguchaja G.Ju.

Dates

1994-03-15—Published

1987-04-17—Filed

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