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Application

4828925/04, 1990-05-25

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Actual filing date

1990-05-25

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Published

1994-04-30

(72)

Inventor

Mashkovskij M.D.Shpakov A.N.Faermark I.F.Shvarts G.Ja.Murugova E.Ju.Romanova O.B.Granik V.G.

DERIVATIVES OF 5-HYDRAZONES-HEXAHYDROCINNOLINE-3,5-DIONES SHOWING ANTIHYPERTENSIVE AND SPASMOLYTIC ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1704421 A1

FIELD: organic chemistry, derivative of cinnaline. SUBSTANCE: products: 5-hydrazone-7,7-dimethyl-2,3,5,6,7,8-hexahydrocinnoline-3,5-dione and 5-hydrazone-7-phenyl-2,3,4,6,7,8-hexahydrocinnoline-3,5-dione. Synthesis is carried out by reaction of corresponding 7-substitute of 3,4-diethoxycarbonyl-1,4,5,6,7,8-hexahydroquinolone-5 and hydrazine hydrate at boiling point for 1 h. Yield, % ; m. p. C; gross-formula; toxicity LD50, mg/kg: a) 77.7; 272-274; C10H14N4O; 1000; b) 79.9; 267-268; C14H14N4O; 1000. Activity of new compounds exceeds that of known one. Synthesized compounds show antihypertensive and spasmolytic activity and can be used in medicine. EFFECT: synthesis of new compounds of class indicated above. 2 tbl

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SU 1 704 421 A1

Authors

Mashkovskij M.D.

Shpakov A.N.

Faermark I.F.

Shvarts G.Ja.

Murugova E.Ju.

Romanova O.B.

Granik V.G.

Dates

1994-04-30—Published

1990-05-25—Filed

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