FIELD: organic chemistry. SUBSTANCE: product: N-acyl derivatives of 4-phenylpyrrolidine-2-ones of the general formula where a) at R2=R3-H, H, R1 dipropylmethyl, 4-chlorophenoxymethyl, 3-pyridyl, 4-chlorophenyl; b) at R2 ethoxycarbonyl and R3 H, R1 - 4-methoxyphenyl, dipropylmethyl; c) at R2-H H and R3 chlorine, R1 4-methoxyphenyl, 4-chlorophenoxymethyl, dipropylmethyl. Synthesis is carried out by reaction of corresponding 4-phenylpyrrolidine-2-ones with corresponding chloroanhydride in toluene in the presence of triethanolamine. Yield, m. p. C or b. p. C (mm mercury column); gross-formula, toxicity (LD50,), mg/kg (i. p.): A0 87, 163-165 (2), C18H25NO2,, 1571; b) 76.5, 127-128, C18H16ClNO3,, above 2000; c) 58.5, 146-147, C16H14N2O2,, above 2000; d) 65.4, 157-158, C17H14ClNO2,, above 2000; e) 66, 137-138, C21H21NO5,, above 2000; f) 76, 50-51, C21H29NO4,, above 2000; g) 79, 200-202/0.5 mm, C18H24ClNO2,, above 2000; h) 59, 163,5-165, C18H16ClNO3,, above 2000; i) 78.6, 181.5-183, C18H15Cl2NO3,, above 2000. Antiamnestic effect of new compounds is 10-100 time more than that of pyracetam. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis. 5 tbl
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Authors
Dates
1995-10-10—Published
1990-05-30—Filed