FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel benzimidazole compounds presented by the general formula (I): where o means number 0, 1, 2 or 3; R1 means alkyl group, phenyl group or monocyclic heterocyclic group comprising N or O as heteroatom being these groups can be substituted once or more times with substitutes taken among alkyl, cycloalkyl, cycloalkylalkyl, alkoxy-, cyano-, amino- and nitro-group; or R1 means cyano-group or group of the formula alkyl-CO2R2, alkenyl-CO2R2, -CO-R2, -
or -C(R3)=N-OR2 where m means number 0, 1, 2 or 3; R2 means hydrogen atom, alkyl, phenyl, benzyl, 5- or 6-membered heterocyclic group being this 5- or 6-membered group can be substituted possibly with once or more times with alkyl or alkoxy-group; or R2 can means group of the formula
or alkyl-CO2R4 where R4 and R5 mean independently hydrogen atom or alkyl, and q means number 0, 1, 2 or 3; R3 means hydrogen atom or alkyl; R11 means group of the general formula
where R9 means alkyl; or R9 can mean 6-membered heterocyclic group being this 6-membered heterocyclic group can be possibly substituted once or more times with alkyl or alkoxy-group; or R9 means group of the general formula -alkyl-N(R10R12) where R10 and R12 mean independently hydrogen atom or alkyl; or R11 means group of the general formula (II):
where n means number 0, 1, 2 or 3; R′ and R″ in common with N atom to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can comprise possibly one oxygen atom and/or additional nitrogen atom as a member of ring; also in this formula heterocyclic ring with members number from 5 to 7 formed by R′ and R″ can be possibly substituted once or more times with group of the formula
where p means number 0, 1, 2 or 3; X means hydrogen atom, hydroxyl, alkyl or alkenyl being these alkyl and alkenyl can be possibly substituted one or more times with group of the formula
; or X means group of the formula
or -CON-R6R7 being in these formulas R6 and R7 mean independently hydrogen atom or alkyl; or R11 can mean group of the general formula (III):
where n means number 1; R′ means hydrogen atom or alkyl; R′′′ and R′′′′ in common with atoms to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can possibly comprise a single chain -CH=CH- as a member ring; also, in this formula heterocyclic ring with members number from 5 to 7 formed by R′′′ and R′′′′ can be possibly substituted once or more times with group of the formula
where p means number 0, 1, 2 or 3; X means hydrogen atom, alkyl; or its pharmaceutically acceptable salt under condition that if R11 means morpholinyl then R1 can't mean tert.-butyl. Invention relates also to pharmaceutical composition showing properties of modulator of ABAHPC-receptors and to method of treatment of disorders and diseases of live body being this disorder or disease is sensitive to modulation of ABAHPC- receptor complex of the central nervous system. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 14 cl, 7 tbl, 38 ex
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Authors
Dates
2002-12-20—Published
1997-10-21—Filed