1-PHENYLBENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF DISORDER OR DISEASES SENSITIVE TO MODULATION OF AMINOBUTYRIC ACID HETEROPENTAMERIC COMPLEX (ABAHPC)-RECEPTOR COMPLEX OF CENTRAL NERVOUS SYSTEM Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel benzimidazole compounds presented by the general formula (I): where o means number 0, 1, 2 or 3; R¹ means alkyl group, phenyl group or monocyclic heterocyclic group comprising N or O as heteroatom being these groups can be substituted once or more times with substitutes taken among alkyl, cycloalkyl, cycloalkylalkyl, alkoxy-, cyano-, amino- and nitro-group; or R¹ means cyano-group or group of the formula alkyl-CO₂R², alkenyl-CO₂R², -CO-R², - or -C(R³)=N-OR² where m means number 0, 1, 2 or 3; R² means hydrogen atom, alkyl, phenyl, benzyl, 5- or 6-membered heterocyclic group being this 5- or 6-membered group can be substituted possibly with once or more times with alkyl or alkoxy-group; or R² can means group of the formula or alkyl-CO₂R⁴ where R⁴ and R⁵ mean independently hydrogen atom or alkyl, and q means number 0, 1, 2 or 3; R³ means hydrogen atom or alkyl; R¹¹ means group of the general formula where R⁹ means alkyl; or R⁹ can mean 6-membered heterocyclic group being this 6-membered heterocyclic group can be possibly substituted once or more times with alkyl or alkoxy-group; or R⁹ means group of the general formula -alkyl-N(R¹⁰R¹²) where R¹⁰ and R¹² mean independently hydrogen atom or alkyl; or R¹¹ means group of the general formula (II): where n means number 0, 1, 2 or 3; R′ and R″ in common with N atom to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can comprise possibly one oxygen atom and/or additional nitrogen atom as a member of ring; also in this formula heterocyclic ring with members number from 5 to 7 formed by R′ and R″ can be possibly substituted once or more times with group of the formula where p means number 0, 1, 2 or 3; X means hydrogen atom, hydroxyl, alkyl or alkenyl being these alkyl and alkenyl can be possibly substituted one or more times with group of the formula ; or X means group of the formula or -CON-R⁶R⁷ being in these formulas R⁶ and R⁷ mean independently hydrogen atom or alkyl; or R¹¹ can mean group of the general formula (III): where n means number 1; R′ means hydrogen atom or alkyl; R′′′ and R′′′′ in common with atoms to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can possibly comprise a single chain -CH=CH- as a member ring; also, in this formula heterocyclic ring with members number from 5 to 7 formed by R′′′ and R′′′′ can be possibly substituted once or more times with group of the formula where p means number 0, 1, 2 or 3; X means hydrogen atom, alkyl; or its pharmaceutically acceptable salt under condition that if R¹¹ means morpholinyl then R¹ can't mean tert.-butyl. Invention relates also to pharmaceutical composition showing properties of modulator of ABAHPC-receptors and to method of treatment of disorders and diseases of live body being this disorder or disease is sensitive to modulation of ABAHPC- receptor complex of the central nervous system. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 14 cl, 7 tbl, 38 ex