1,2,3,6-TETRAHYDROPYRROLO [1,2-d][1,4]DIAZOCINES DERIVATIVES PREPARATION METHOD Russian patent published in 2010 - IPC C07D487/06 

FIELD: chemistry.

SUBSTANCE: described is a method for preparation of a new class compounds represented by 1,2,3,6-tetrahydropropyrrolo[1,2-d][1,4]diazocine derivatives with a general formula of I-VI , where: I R¹=Me R²=Me R³=CHO X=CO₂Me; II R¹=Et R²=MeR³=CHO X=CO₂Me; III R¹=Et R²=Me R³=CF₃CO a) X=CO₂Me, b) X=COMe; IV R¹=Bn R²=Me R³=CHO X=CO₂Me; V R¹=Me R²=Ph R³=CHO a) X=CO₂Me, b) X=COMe; VI R¹=Me R²=Ph R³=CF₃CO a) X=CO₂Me, b) X=COMe that may be of interest in the capacity of nootropic preparations. The proposed method is as follows: the relevant 1,2,3,4-tetrahydropropyrrolo[1,2-a][1,4]diazocine derivative becomes dissolved in acetonitrile and undergoes interaction with two moles of H-C≡C-X compound in combination with boiling during at least 7 hours, the residue produced after the reaction termination the solvent removal becomes purified by way of aluminium oxide column chromatography.

EFFECT: method for preparation of a new class compounds.

1 cl, 9 ex