Patenton — panteon of patents

(19)

SU

(11)

1 804 716

(13)

A3

(51)

IPC

(21) (22)

Application

4871644/04, 1990-08-22

(22)

Actual filing date

1990-08-22

(45)

Published

1994-10-15

(72)

Inventor

Glushkov R.G.L'Vov A.I.Davydova N.K.Sizova O.S.Sanzharova G.M.Poljakova M.Ja.

(73)

Holder

Tsentr Po Khimii Lekarstvennykh Sredstv

PROCESS FOR PREPARING 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANIC ACID Russian patent published in 1994 - IPC

Abstract SU 1804716 A3

FIELD: medicine. SUBSTANCE: the product: 5-(2.5-dimethyl- phenoxy)-2.2-dimethylpentanic acid of the empirical formula: C15H22O3, mp 61-63 C (from hexane), ex. 19. Reagent 1: 2.5-dimethylphenol. Reagent 2: ethyleneketal-5-chloro-2-pentanone. Reaction conditions: the polar organic solvent is dimethylformamide or dimethylformamide in admixture with a solvent which forms azeotrope with water, an alkali agent; the reaction mixture is boiled to form ethyleneketal 5-(2.5-dimethylphenoxy)-2-pentanone which is hydrolyzed in the presence of a mineral acid to obtain 5-(2.5-dimethilphenoxy)-2-pentanone which is then reacted with methylmagnesium iodide and the resultant 5-(2.5- dimethylphenoxy)-2-methylpentanol is treated with 2-formic acid in a concentrated sulfuric acid solution in the presence of cuprous oxide. EFFECT: improved properties of the title product. 1 tbl

Similar patents SU1804716A3

Title Year Author Number
METHOD OF SYNTHESIS OF 3-BROMO-4-HYDROXYBENZALDEHYDE 1991
  • Afanas'Eva V.L.
  • Glushkov R.G.
  • Erofeev Ju.V.
  • Kovaleva S.S.
 RU2024482C1
3-PHENYL-10H-4,5-DIHYDROPYRAZOLO[4,3-A]CARBAZOLE SHOWING ANTITUMOR AND ANTILEUKEMIC ACTIVITY 1991
  • Sokolova A.S.
  • Bogomolova N.S.
  • Romanova O.B.
  • Granik V.G.
 RU2007394C1
4-ACETYL -7- BROMOIMIDAZO -[4,5-B] -INDOLE -2-THIONE SHOWING CAPABILITY TO RECOVERY WORKING CAPACITY, AND A METHOD OF ITS SYNTHESIS 1991
  • Velezheva V.S.
  • Mel'Man A.I.
  • Tomchin A.B.
  • Marysheva V.V.
  • Spivakova R.P.
  • Smirnov A.V.
 RU2024525C1
N-PHOSPHORYLATED DERIVATIVES OF 3-β- PHENYLISOPROPYLSYDNONEIMINE SHOWING ANTITUMOR ACTIVITY 1991
  • Sokolova A.S.
  • Borisov E.V.
  • Vasil'Ev A.V.
  • Parshin V.A.
  • Zabrodin V.B.
  • Safonova T.S.
 RU2036914C1
METHOD FOR PREPARING 1-ALKOXYCARBONYLMETHYLPYRROLIDONES-2 1992
  • Granik V.G.
  • Grizik S.I.
  • Golovko T.V.
  • Kuzovkin V.A.
  • Budanova L.I.
  • Volzhina O.N.
  • Glushkov R.G.
 RU2032668C1
PROCESS FOR PREPARING 2,6-DICHLORODIPHENYLAMINE 1992
  • Rjabova S.Ju.
  • Bokanov A.I.
  • Isakovich I.P.
  • Kuzovkin V.A.
  • Grigor'Ev N.B.
  • Levina V.I.
  • Shvedov V.I.
  • Granik V.G.
 RU2061676C1
METHOD OF 2-ALKYLAMINOMETHYLENE-3,9-DIOXOPYRROLO(1,2-A)INDOLES SYNTHESIS 0
  • Ryabova Svetlana Yurevna
  • Granik Vladimir Grigorevich
 SU1735285A1
DERIVATIVES OF 4-ACETYLIMIDAZO-[4,5-B]-INDOLE-2-THIONE SHOWING ANTIHYPOXIC AND VIRUS-INHIBITING ACTIVITY WITH RESPECT TO HORSE VENEZUELAN ENCEPHALOMYELITIS AND METHOD OF THEIR SYNTHESIS 1991
  • Velezheva V.S.
  • Mel'Man A.I.
  • Tomchin A.B.
  • Katkov V.F.
  • Smushkevich Ju.I.
  • Smirnov A.V.
  • Fomina A.N.
  • Nikolaeva I.S.
  • Il'Ina M.G.
 RU2091382C1
DERIVATIVES OF PYRIDO(3,2-A)-CARBAZOLE HAVING CARDIOTONIC ACTIVITY 1991
  • Granik V.G.
  • Grizik S.I.
  • Shanazarov A.K.
  • Mashkovskij M.D.
  • Juzhakov S.D.
  • Dolgun O.V.
  • Denisov A.V.
  • Ivanjuk T.V.
 RU2032685C1
DERIVATIVES OF 5-HYDRAZONES-HEXAHYDROCINNOLINE-3,5-DIONES SHOWING ANTIHYPERTENSIVE AND SPASMOLYTIC ACTIVITY 1990
  • Mashkovskij M.D.
  • Shpakov A.N.
  • Faermark I.F.
  • Shvarts G.Ja.
  • Murugova E.Ju.
  • Romanova O.B.
  • Granik V.G.
 SU1704421A1

SU 1 804 716 A3

Authors

Glushkov R.G.

L'Vov A.I.

Davydova N.K.

Sizova O.S.

Sanzharova G.M.

Poljakova M.Ja.

Dates

1994-10-15—Published

1990-08-22—Filed

read Similar patents