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2 091 382

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IPC

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Application

4903335/04, 1991-01-21

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Actual filing date

1991-01-21

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Published

1997-09-27

(72)

Inventor

Velezheva V.S.Mel'Man A.I.Tomchin A.B.Katkov V.F.Smushkevich Ju.I.Smirnov A.V.Fomina A.N.Nikolaeva I.S.Il'Ina M.G.

(73)

Holder

Tsentr Po Khimii Lekarstvennykh Sredstv

DERIVATIVES OF 4-ACETYLIMIDAZO-[4,5-B]-INDOLE-2-THIONE SHOWING ANTIHYPOXIC AND VIRUS-INHIBITING ACTIVITY WITH RESPECT TO HORSE VENEZUELAN ENCEPHALOMYELITIS AND METHOD OF THEIR SYNTHESIS Russian patent published in 1997 - IPC

Abstract RU 2091382 C1

FIELD: organic chemistry. SUBSTANCE: product: compound of the general formula where: R - hydrogen atom, methyl, benzyl. Reagent 1: 1-acetyl-2-amylamino-3-indolinone hydrochloride. Reagent 3: potassium thiocyanate, in acetic acid medium, at boiling. Reagent 4: 1-acetyl-2-alkylthioureido-3-indolinone. Method involves cyclization with a mixture of phosphoric anhydride and 87% phosphoric acid. Reaction is carried out in medium of diethylene glycol dimethyl ether at 100-160 C. EFFECT: improved method of synthesis. 2 cl, 5 tbl

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RU 2 091 382 C1

Authors

Velezheva V.S.

Mel'Man A.I.

Tomchin A.B.

Katkov V.F.

Smushkevich Ju.I.

Smirnov A.V.

Fomina A.N.

Nikolaeva I.S.

Il'Ina M.G.

Dates

1997-09-27—Published

1991-01-21—Filed

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