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1 824 738

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IPC

(21) (22)

Application

4934900/14, 1991-05-08

(22)

Actual filing date

1991-05-08

(45)

Published

1995-05-10

(72)

Inventor

Andreev S.M.Babakhin A.A.Tsvetkov D.E.Poznakhirev P.R.Gushchin I.S.Khaitov R.M.Petrov R.V.

METHOD OF PREPARING OF MODIFIED ALLERGENS Russian patent published in 1995 - IPC

Abstract SU 1824738 A1

FIELD: immunobiotechnology. SUBSTANCE: method involves conjugation of allergen with copolymer of N-vinylpyrrolidone and maleic anhydride with molecular mass 30-70 kDa modified with ε-aminocaproic acid and activated with N-hydroxysuccinimide at the mass ratio allergen:polymer from 2:5 to 3:2. In prepared new polymer-protein conjugates the parental protein losses expressed properties for induction of IgE-antibody formation but capability for induction of antibodies of class IgG is retained. EFFECT: decreased allergenicity of immunogens. 2 tbl

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SU 1 824 738 A1

Authors

Andreev S.M.

Babakhin A.A.

Tsvetkov D.E.

Poznakhirev P.R.

Gushchin I.S.

Khaitov R.M.

Petrov R.V.

Dates

1995-05-10—Published

1991-05-08—Filed