FIELD: organic chemistry. SUBSTANCE: product: crystals of 7 - b - [(Z) - 2 - (5 - amino - 1,2,4 - thiadiazole - 3 - yl) - 2 - methoxyiminoacetamido] - 3 - [1 - imideazo(1,2 - b) - pyridazine] - methyl - 3 - cepheme - 4 - carboxylate hydrochloride hydrate of the general formula I, where X - from 0,2 to 4,9, or its solvates containing 0,8-1,2 mole of solvent taken from a group involving acetone, methanol, ethanol or dimethylformamide. Reagent 1: or its hydrate. Reagent 2: hydrogen chloride or hydrochloric acid. Reaction condition: in the medium of organic solvent. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 14 dwg
| Title |
Year |
Author |
Number |
| PROCESS FOR PRODUCING ACID-ADDITIVE SALTS OF PIVALOYLHYDROXYMETHYL ESTER OF 7-BETA-(2-(2-AMINOTHIAZOL-4-YL)-ACETAMIDO)-3-(1-(2-DIMETHYLAMINOETHYL)-1H-TETRAZOL-5-YLTHIOMETHYL)-3-CEPHEM-1-CARBOXYLIC ACID WITH HYDROCHLORIC, TARTARIC OR CITRIC ACID |
0 |
- Esinobu Esimura
- Nobukhide Morikava
- Kunio Takanokhasi
|
SU973024A3 |
| DERIVATIVES OF 1,2,4-TRIAZOLE, OPTICALLY INERT OR CONTAINING R- OR S-CONFIGURATION AT C-2 AND C-3 ASYMMETRIC CENTERS, OR THEIR SALTS SHOWING FUNGICIDE ACTIVITY, AND A METHOD OF THEIR SYNTHESIS |
1990 |
- Katsumi Itokh[Jp]
- Kendzi Okonogi[Jp]
|
RU2039050C1 |
| METHOD OF SYNTHESIS OF CEPHALOSPORIN DERIVATIVES OR THEIR SALTS |
1990 |
- Akio Mijake[Jp]
- Masakhiro Kondo[Jp]
- Masakhiko Fudzino[Jp]
|
RU2024529C1 |
| HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO ANGIOTENSIN-II AND A METHOD OF ANTAGONIZATION OF ANGIOTENSIN-II IN MAMMALS |
1992 |
- Takekhiko Naka[Jp]
- Esijuki Finada[Jp]
|
RU2104276C1 |
| METHOD OF CEPHALOSPORINE DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS SYNTHESIS |
0 |
- Akio Miyake
- Masakhiro Kondo
- Masakhiko Fudzino
|
SU1788955A3 |
| BENZIMIDAZOLE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS |
1991 |
- Takekhiko Naka[Jp]
- Kokhei Nisikava[Jp]
|
RU2057126C1 |
| SULFUR-CONTAINING HETEROCYCLIC COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
1989 |
- Takasi Sokhda[Jp]
- Masao Tsuda[Jp]
- Ivao Jamazaki[Jp]
|
RU2041875C1 |
| DERIVATIVES OF 2,4-OXAZOLIDINEDIONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF SYNTHESIS, MEDICINAL COMPOSITION SHOWING HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECT, METHOD OF BLOOD GLUCOSE AND LIPID CONTENT DECREASE IN MAMMALIAN WITH DIABETES MELLITUS OR HYPERLIPIDEMIA |
1994 |
- Takasi Sokhda
- Khitosi Ikeda
- Ju Momose
- Satiko Imai
|
RU2126797C1 |
| METHOD OF SYNTHESIS OF BENZIMIDAZOLE DERIVATIVES OR THEIR SALTS |
1990 |
- Takekhiko Naka[Jp]
- Kokhei Nisikava[Jp]
|
RU2023713C1 |
| CYCLIC AMINOCOMPOUND OR ITS PHYSIOLOGICALLY ACCEPTABLE ADDITIVE ACID SALT |
1990 |
- Goto Giiti[Jp]
- Jukimasa Khidefumi[Jp]
- Imamoto Tetsudzi[Jp]
|
RU2021989C1 |
