DERIVATIVES OF 2,4-OXAZOLIDINEDIONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF SYNTHESIS, MEDICINAL COMPOSITION SHOWING HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECT, METHOD OF BLOOD GLUCOSE AND LIPID CONTENT DECREASE IN MAMMALIAN WITH DIABETES MELLITUS OR HYPERLIPIDEMIA Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to derivatives of 2,4-oxazolidine-dione of the general formula (I) where R is C_1-8--alkyl, pyridyl possibly condensed with benzene ring or 5-membered aromatic heterocyclic group containing one nitrogen atom and one oxygen atom or one sulfur atom or three nitrogen atoms being the indicated groups can be substituted with C_1-15-alkyl possibly substituted halide, C_2-10-alkenyl substituted with phenyl, phenyl possibly substituted with halide or lower alkyl, naphthyl, furyl, thienyl, benzofuranyl, benzo[b]thienyl; Y means -CO-, -CH(OH)- or -NR³- where R³ is -C_1-4-alkyl; m = 0 or 1; n = 0, 1 or 2; X is -CH or N; A - divalent direct or branched residue of hydrocarbon chain containing 1-7 carbon atoms; R¹ and R² - hydrogen or C_1-4-alkyl, or R¹ and R² form 5-6-membered heterocyclic system optionally containing nitrogen; L and M are connected each with other forming a bond, or their pharmaceutically acceptable salt. Compounds of the formula (I) decrease blood glucose, show low toxicity and can be used in drug compositions for treatment of mammalian including human with diabetes mellitus. EFFECT: improved method of synthesis, enhanced effectiveness of treatment. 32 cl, 12 tbl, 90 ex