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2 007 415

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IPC

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Application

5024207/04, 1991-10-11

(22)

Actual filing date

1991-10-11

(45)

Published

1994-02-15

(72)

Inventor

Nemal'Tsev Ju.V.Tsel' L.R.Ul'Janova N.M.Afanas'Ev V.A.Ostrovskaja L.A.

(73)

Holder

Institut Organicheskoj Khimii An Respubliki Kyrgyzstan

METHYL - 2,4,6 - TRI - O - ACETYL - 3 - DEOXY - 3,3-C - DICYANO - α - D - GLUCOHEXAPYRANOSIDE SHOWING ANTITUMOR ACTIVITY Russian patent published in 1994 - IPC

Abstract RU 2007415 C1

FIELD: organic chemistry. SUBSTANCE: product - methyl - 2,4,6 - tri - O - acetyl - 3 - deoxy - 3,3 - C - dicyano - a - D - glucopyranoside, gross- formula is C15H18O8N2, m. p. is 118-119 C. Reagent 1: methyl - 2,4,6 - tri - O - acetyl - 3 - deoxy - 3 - C - carbamoyl - 3 - C - cyano - LD50 - D - glucopyranoside. Reagent 2: thionyl chloride. Reaction conditions: in the presence of dimethylformamide, at 60 C for 1 h. Value α = 197 mg/kg. After a single administration of synthesized substance inhibition of growth of leukosis tumor P-388, melanoma B-16 and Lewis lung carcinoma is observed (by 75; 88 and 82% , respectively). Synthesized compound can be used in medicine. EFFECT: high antitumor activity of the end product. 1 tbl

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RU 2 007 415 C1

Authors

Nemal'Tsev Ju.V.

Tsel' L.R.

Ul'Janova N.M.

Afanas'Ev V.A.

Ostrovskaja L.A.

Dates

1994-02-15—Published

1991-10-11—Filed

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