METHOD FOR PREPARATION OF CYTOTOXIC CONJUGATION Russian patent published in 1994 - IPC

Abstract RU 2009500 C1

FIELD: treatment of tumors and transplantation practice. SUBSTANCE: conjugating 14-haloidarubicine (1 da) with monoclonal antibody or fragment thereof containing at least one antigen-binding portion of antigen produces cytotoxic conjugation which is cleaned of darubicine by adsorptive or ion-exchange chromatography. EFFECT: intensified cytotoxic effect of conjugation. 2 tbl

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RU 2 009 500 C1

Authors

Jan Fark'Jukhar Kehmpbell Makkenzi[Au]

Dzheffri Allan Piters[Au]

Dates

1994-03-15—Published

1988-03-10—Filed