FIELD: medicine, tumor therapy. SUBSTANCE: method deals with elaborating monoclonal antibody conjugates with 14-bromide-4-dimetoxydaunorubicin. At the same time conjugate contains 2-8 molecules of medicine covalently connected with antibody or fragment and developing pharmaceutical composition that contains such a conjugate and also an acceptable diluent or carrier. EFFECT: higher specificity of medicine supply towards tumor. 3 cl, 3 tbl, 19 dwg
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Authors
Dates
1998-03-10—Published
1992-06-15—Filed