4-OXO-1,4-DIHYDROPYRIMIDINE DERIVATIVES HAVING ANTIALLERGIC AND IMMUNOTROPIC ACTIVITY Russian patent published in 1994 - IPC

FIELD: chemico-pharmaceutical industry and medicine. SUBSTANCE: 4-oxo-1,4-dihydropyrimidime DERIVATIVES of the formula: having antiallergic and immunotropic activity. Reagent 1: 2,6-dimethyl-1,5-diphenyl-4-oxo-1,4-dihydropyrimidine or 2.5-dimethyl-5-phenyl-1-(3-pyridinyl)-4-oxo-1,4-dihydropyridine. Reagent 2: 4-methoxybenzaldehyde, 4-hydroxybenzaldehyde. The process is carried out in a mixture of dimethyl sulfoxide and ethanol on boiling; the yield is 53-71%. R₁-C₆H₅ R₂-OCH₃; the molecular weight is 394; mp 261-263 C; C₂₀H₁₉N₂O, R₁-C₆H₅, R₂-OH, the molecular weight is 380 mp 317-319 C; C₁₉H₁₇N₂O₂, R₁-C₆H₅, R₂-3-pyridyl; the molecular weight is 395; mp 238-241 C, C₂₇H₁₈N₃O com pounds are nontoxic (LD₅₀ mg/kg) and have marked antiallergic and immunostimulating activity. EFFECT: improved properties of the title compounds. 3 tbl