4-CHROMENYLIDENE DERIVATIVES WITH ANTIALLERGIC ACTIVITY Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: product- 4-chromenylidene derivatives : a) diethylaminoethyl N-[2-(4-hydroxyphenyl)-6-acetyl-7-hydroxychromenyl-4-idene] -p-aminobenzoate, -C₃₀H₃₀N₂O₆, m. p. 250 C (from ethanol), b) diethylaminoethyl N-[2-(4-hydroxyphenyl)-6-chlorochromenyl-4-idene] -p-aminobenzoate, C₂₈H₂₇N₂O₄Cl, m. p. 165-166 C (from ethanol), c) diethylaminoethyl N-[2-(4-dimethylaminophenyl)-7-acetoxychromenyl-4-idene] -p-aminobenzoate, C₃₂H₃₅N₃O₅, m. p. 232-233 C (from ethanol). Reaction conditions: condensation of 4-ethoxyflavilium perchlorates with corresponding derivatives containing amino group in acid medium. EFFECT: increased antiallergic activity. 1 tbl