PROCESS FOR PREPARING DI-P-TOLUYL-L-TARTARIC ACID SALT OF 1-[1,2, 3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO(2,3-B)INDOL-5-YL]-2 PROPANONE Russian patent published in 1994 - IPC

Abstract RU 2015979 C1

FIELD: medicine. SUBSTANCE: the product: a di-p-toluyl-1-tartaric acid salt of 1-[1,2,3,3a,8,8a-haxahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl] -2-propanone, mp 115-125 C. Reagent 1: 5-bromo-1,2,3,3a,8,8a-hexahydro-1,3a, 8-trimethylpyrrolo(2,3-b)indole. Reagent 2: tributyltinmethoxide and isopropenylacetate. Reagent 3: palladium acetate and tri-0-tolylphosphine. Reagent 4: di-p-toluyl L-tartaric acid. Reaction conditions: a base is prepared in an organic solvent such as toluene, the resulting salt is formed in an ether solvent such as diethyl ether. EFFECT: improved properties of the resulting salt. 1 tbl

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RU 2 015 979 C1

Authors

Richard S.Allen[Us]

Deniz M.Flehnagan[Us]

Dates

1994-07-15Published

1991-05-08Filed