FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes 1,2,3,3a, 8,8a-hexahydro-1,3a-8-trimethylpyrrolo- -[2,3-b]-indole tetrahydroisoquinoline carbamates of the formula (I) 
where R - hydrogen, lower alkyl; X - hydrogen, or their acceptable acid-additive salts. Invention proposes also a pharmaceutical composition and a method of inhibition of acetylcholine esterase activity using the claimed compounds. Synthesized compounds can be used in patients with memory disfunction and with cholinergic deficiency. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 2 ex, 1 tbl
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