METHOD OF SYNTHESIS OF TETRAHYDROBENZIMIDAZOLE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product of the formula (I), where Het - a residue of indole, 2,3-dihydroindole, benzoxazine, dihydrobenzoxazine, phenothiazine, tetrahydroquinoline, benzothiophene, pyrrole, tetrahydroisoquinoline, thiadiazole, pyridine, 2,3-dihydrobenzimidazole, benzofuran, pyrrolidine, pyrimidine, benzimidazole, benzothiazole, quinoline, indazole, cyclopentathiazole, dihydrocyclopentathiazole, carbazole, 2,3-dihydrobenzimidazole-2-one, tetrahydrobenzothiophene, indene, thiophene, indolysidine or furan which can be substituted with 1-3 substituents taken from the group consisting of the lower alkyl group, lower alkenyl group, lower alkinyl group, cycloalkyl-lower alkyl group, aralkyl group, lower alkoxy-group, nitro-group, hydroxyl-group, lower alkoxycarbonyl-group or halide atom. X² - bond linked with carbon atom of heterocyclic ring Het. Reagent 1: heterocyclic compound of the formula (II) where Het and X² - as indicated above. Reagent 2: compound of the formula (III), or its reactive derivative. Synthesized compounds are used as preparations usable as 3-HI₃-receptor antagonists. EFFECT: improved method of synthesis.