CARPAPENEM DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 1997 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: carpapenem derivatives of general formula is which R¹ is lower alkyl which is substituted with hydroxyl or substituted hydroxyl; R² is lower alkyl; R³ is carboxyl which is etherified; R⁴ is H or amino protecting group; R⁵ and _R6, the same or different, are hydrogen, hydroxy or halogen; R⁷ is hydrogen, lower alkyl or carboxy; R⁸ is hydrogen, lower alkyl or hydroxy lower alkyl; or R⁷ and R⁸ taken together form (C₂-C₆) alkylene; R⁹ and R¹⁰, the same or different, form amino protecting group, hydrogen or lower alkyl; Z is single bond, O,S or CR¹¹R¹² or NR¹³-CO in which R¹¹ and R¹², the same or different, are hydrogen, hydroxy or lower alkyl, and R¹³ is hydrogen; m and n are integers of 0 to 6, and pharmaceutically acceptable salts thereof. The claimed compounds have antibacterial activity. EFFECT: improved properties. 6 cl