DERIVATIVES OF TRIFLUOROMETHYLKETONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of trifluoromethylketone of the formula: where: R₁ - lower alkyl containing one or two substituents taken from carboxy, esterified carboxy, di-lower alkylcarbamoyl, phenyl-(lower)-alkyl phenyl moiety of which can has haloid, nitro- or amino-group and alkyl moiety - carboxy or esterified carboxy, haloidphenyl, morpholine, morpholino-(lower)-alkyl; R² and R³ - lower alkyl; X - bond or NH; Y - or , or their pharmaceutically acceptable salts. Synthesis involves the use of reagent 1: and reagent 2: amine: R¹NH₂. The end product is isolated as free form or as salt. Pharmaceutical composition inhibits activity of leukocyte elastase and contains derivative of trifluoromethylketone as an active component at amount 1 mg - 1 g (as measured for daily dose). EFFECT: improved method of synthesis. 8 cl, 4 tbl