FIELD: organic chemistry. SUBSTANCE: product of the formula (I) (image) where R1 - C3-C6-alkyl substituted with C3-C6-cycloalkyl; R2 and R3 - independently mean hydrogen or C1-C6-alkyl; R4 and R5 - independently mean hydrogen, C1-C6-alkyl, halide, cyano, nitro or trifluoromethyl; or pharmaceutically acceptable salts. Reagent 1: corresponding 4,5,6,7- tetrahydroimidazo -[4,5-ik] [1,4]-benzodiazepine -2-one. Reagent 2: halide. Reagent 3: thiourea. Reaction conditions: in the medium of inert organic solvent. EFFECT: improved method of synthesis. 3 tbl
| Title |
Year |
Author |
Number |
| TETRAHYDROIMIDAZO-[1,4]-BENZODIAZEPINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS, A METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND ANTIVIRAL COMPOSITION |
1992 |
- Mikhail Zhozef Kjukla[Us]
- Anri Zhozef Breslin[Us]
- Al'Fons German Margarita Rajmaker[Be]
- Zhozefjus Ljudovikjus Jubertjus Van Gelder[Be]
- Pol' Adrian Zhan Zhansen[Be]
|
RU2099341C1 |
| METHOD FOR SYNTHESIS OF TETRAHYDROIMIDAZO-(1,4)- BENZODIAZEPINE-12-ONЪS OR THEIRS JOINING SALTS OR PHARMACEUTICALLY ACCEPTABLE ACIDS OR THEIRS STEREOCHEMICALLY ISOMERIC FORMS |
0 |
- Alfons Kherman Margareta Rejmakers
- Jozefus Lyudovikus Khubertus Van Gelder
- Majkl Dzhozef Kukla
- Genri Dzhozef Breslin
- Pol Adrian Yan Zhanssen
|
SU1748647A3 |
| SUBSTITUTED DERIVATIVES OF DIAMINO-1,3,5-TRIAZINE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1997 |
- Kukla Majkl Dzhozef
- Ljudovisi Donal'D V.
- Zhansen Pol' Adrian Zhan
- Geres Jan
- Merel' Anri Ehmil' Lodevijk
|
RU2186774C2 |
| DERIVATIVES OF IMIDEAZOQUINAZOLINE SHOWING POSITIVE INOTROPIC AND LUSITROPIC PROPERTIES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT |
1990 |
- Ehddi Zhan Ehdgar Frejn[Be]
- Al'Fons German Margarita Rajmakers[Be]
|
RU2057753C1 |
| DERIVATIVES OF PYRAMIDINE-4-ONE OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND SEROTONIN-ANTAGONISTIC, DOPAMINE-ANTAGONISTIC AND ANTIGISTAMINE COMPOSITION ON THEIR BASES |
1990 |
- Lido Ehdmon Zhozefin Kennis[Be]
- Jan Vandenberk[Be]
- Jozef Martin Buj[Be]
|
RU2028297C1 |
| HYDROXYALKYLFURAN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1990 |
- Frans Ehduard Zhanssens[Be]
- Gaston Stanislas Marsella Dils[Be]
- Zhozef Ehlizaber Lenarts[Be]
|
RU2030415C1 |
| 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5-(2H,4H)-DIONES SHOWING ANTICOXIDIAL AND COXIDIOSTATIC ACTIVITY |
1987 |
- Gustaf Marija Buks[Be]
- Al'Fons Kherman Margareta Raimakers[Be]
- Viktor Sipido[Be]
|
RU2017736C1 |
| METHOD OF SYNTHESIS OF DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE, OR THEIR SALTS, OR THEIR STEREOCHEMICALLY ISOMERIC FORM |
1990 |
- Zhorzh Anri Pol' Van Del'[Be]
- Frans Marija Al'Fons Van Den Kejbus[Be]
|
RU2037492C1 |
| DERIVATIVES OF 6-ARYL-5,6-DIHYDROIMIDAZO-[2,1-B]-THIAZOLE OR THEIR PHARMACEUTICALLY ACCEPTABLE ACIDIC SALTS, OR THEIR STEREOCHEMICAL ISOMERIC FORMS SHOWING IMMUNOSTIMULATING ACTIVITY, METHOD OF SYNTHESIS, 2-IMINOTHIAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACIDIC SALTS, OR THEIR STEREOCHEMICAL ISOMERIC FORMS AS INTERMEDIATE PRODUCTS FOR SYNTHESIS OF DERIVATIVES OF 6-ARYL-5,6-DIHYDROIMIDAZO-[2,1-B]-THIAZOLE, IMMUNOSTIMULATING COMPOSITION |
1990 |
- Al'Fons German Margareta Rajmakers[Be]
- Leopol'D Frans Kornel Ruvens[Be]
- Villi Jokhannes Karolus Van Laroven[Be]
- Zhan P'Er Frans Van Vauve[Be]
|
RU2051153C1 |
| SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITIVE SALTS, METHOD FOR THEIR PRODUCTION AND COMPOSITION POSSESSING ANTIALLERGIC ACTIVITY |
1991 |
- Frans Ehduard Zhanssen[Be]
- Fransua Maria Sommen[Be]
- Gaston Stanislas Marsella Diel[Be]
|
RU2067978C1 |
